ABSTRACT
Ultrasonography has been recognized as an important diagnostic modality in medicine and has entered the area of clinical dermatology. Its non-invasive characteristics have made it easily use and completely safe. It provides important diagnostic information in evaluating skin tumors. It also outlines the subcutaneous lesions and their relation to its adjacent tissue. Another ultrasound technique is color Doppler which is useful to assess vascularization of skin lesion. In this article, we would like to report ultrasound imaging in some selected cases from our institution.
Subject(s)
Skin DiseasesABSTRACT
The GATM gene encodes L-arginine:glycine amidinotransferase, which catalyzes the conversion of L-arginine into guanidinoacetate, the rate-limiting step in the synthesis of creatine. Since, deficiencies in creatine synthesis and transport lead to certain forms of mental retardation in human, the human GATM gene appears to be involved in brain development. Recently it has been demonstrated that the mouse Gatm is expressed during development and is imprinted with maternal expression in the placenta and yolk sac, but not in embryonic tissues. We investigated the imprinting status of the human GATM by analyzing its expression in four human placentas. GATM was biallelically expressed, thus suggesting that this gene escapes genomic imprinting in placentas, differently from what has been reported in mouse extra-embryonic tissues.